Overcomplete sets in non-separable Banach spaces

We introduce and study the notion of overcomplete set in a Banach space, that subsumes and extends the classical concept of overcomplete sequence in a (separable) Banach space. We give existence and non-existence results of overcomplete sets for a wide class of (non-separable) Banach spaces and we study to which extent properties of overcomplete sequences are retained by every overcomplete set

Banach spaces of continuous functions without norming Markushevich bases

We investigate the question whether a scattered compact topological space $K$ such that $C(K)$ has a norming Markushevich basis (M-basis, for short) must be Eberlein. This question originates from the recent solution, due to H\'ajek, Todor\v{c}evi\'c, and the authors, to an open problem from the Nineties, due to Godefroy. Our prime tool consists in proving that $C([0,\omega_1])$ does not embed in a Banach space with a norming M-basis, thereby generalising a result due to Alexandrov and Plichko. Subsequently, we give sufficient conditions on a compact $K$ for $C(K)$ not to embed in a Banach space with a norming M-basis. Examples of such conditions are that $K$ is a $0$-dimensional compact space with a P-point, or a compact tree of height at least $\omega_1 +1$. In particular, this allows us to answer the said question in the case when $K$ is a tree and to obtain a rather general result for Valdivia compacta. Finally, we give some structural results for scattered compact trees; in particular, we prove that scattered trees of height less than $\omega_2$ are Valdivia

Why does epithelia display heterogeneity?:Bridging physical and biological concepts

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Quasi-static and low-velocity impact behavior of intraply hybrid flax/basalt composites

In an attempt to increase the low-velocity impact response of natural fiber composites, a new hybrid intraply woven fabric based on flax and basalt fibers has been used to manufacture laminates with both thermoplastic and thermoset matrices. The matrix type (epoxy or polypropylene (PP) with or without a maleated coupling agent) significantly affected the absorbed energy and the damage mechanisms. The absorbed energy at perforation for PP-based composites was 90% and 50% higher than that of epoxy and compatibilized PP composites, respectively. The hybrid fiber architecture counteracted the influence of low transverse strength of flax fibers on impact response, irrespective of the matrix type. In thermoplastic laminates, the matrix plasticization delayed the onset of major damage during impact and allowed a better balance of quasi-static properties, energy absorption, peak force, and perforation energy compared to epoxy-based composites

Countering Misinformation via Emotional Response Generation

The proliferation of misinformation on social media platforms (SMPs) poses a significant danger to public health, social cohesion and ultimately democracy. Previous research has shown how social correction can be an effective way to curb misinformation, by engaging directly in a constructive dialogue with users who spread -- often in good faith -- misleading messages. Although professional fact-checkers are crucial to debunking viral claims, they usually do not engage in conversations on social media. Thereby, significant effort has been made to automate the use of fact-checker material in social correction; however, no previous work has tried to integrate it with the style and pragmatics that are commonly employed in social media communication. To fill this gap, we present VerMouth, the first large-scale dataset comprising roughly 12 thousand claim-response pairs (linked to debunking articles), accounting for both SMP-style and basic emotions, two factors which have a significant role in misinformation credibility and spreading. To collect this dataset we used a technique based on an author-reviewer pipeline, which efficiently combines LLMs and human annotators to obtain high-quality data. We also provide comprehensive experiments showing how models trained on our proposed dataset have significant improvements in terms of output quality and generalization capabilities.Comment: Accepted to EMNLP 2023 main conferenc

Effect of temperature on the low-velocity impact response of environmentally friendly cork sandwich structures

Impact events are common in every-day life and can severely compromise the integrity and reliability of high-performing structures such as sandwich composites that are widespread in different industrial fields. Considering their susceptibility to impact damage and the environmental issues connected with their exploitation of synthetic materials, the present work aims to propose a bio-based sandwich structure with an agglomerated cork core and a flax/basalt intraply fabric as skin reinforcement and to address its main weakness, i.e. its impact response. In-service properties are influenced by temperature, therefore the effect of high (60 °C) and low (−40°C) temperatures on the impact behavior of the proposed structures was investigated and a suitable comparison with traditional (polyvinyl chloride) (PVC) foams was provided. The results highlighted the embrittlement effect of decreasing temperature on the impact resistance of the sole cores and skins and of the overall structures with a reduction in the perforation energy that shifted, in the last case, from 50–60 J at – 40 °C up to more than 180 J at 60 °C. A maleic anhydride coupling agent in the skins hindered fundamental energy dissipation mechanisms such as matrix plasticization, determining a reduction in the perforation threshold of all composites. In particular, neat polypropylene (PP) skins displayed a perforation energy of 20 J higher than compatibilized (PPC) ones at 60 °C, while agglomerated cork sandwich structures at 60 °C were characterized by a perforation threshold higher of at least 50 J.Publicad

Pain Modulation in WAG/Rij Epileptic Rats (A Genetic Model of Absence Epilepsy): Effects of Biological and Pharmacological Histone Deacetylase Inhibitors

Epigenetic mechanisms are involved in epilepsy and chronic pain development. About that, we studied the effects of the natural histone deacetylase (HDAC) inhibitor sodium butyrate (BUT) in comparison with valproic acid (VPA) in a validated genetic model of generalized absence epilepsy and epileptogenesis. WAG/Rij rats were treated with BUT (30 mg/kg), VPA (300 mg/kg), and their combination (BUT + VPA) daily per os for 6 months. Rats were subjected at Randall-Selitto, von Frey, hot plate, and tail flick tests after 1, 3, and 6 months of treatment to evaluate hypersensitivity to noxious and non-noxiuous stimuli. Moreover, PPAR-γ (G3335 1 mg/kg), GABA-B (CGP35348 80 mg/kg), and opioid (naloxone 1 mg/kg) receptor antagonists were administrated to investigate the possible mechanisms involved in analgesic activity. The expression of NFkB, glutathione reductase, and protein oxidation (carbonylation) was also evaluated by Western blot analysis. WAG/Rij rats showed an altered pain threshold throughout the study (p < 0.001). BUT and BUT + VPA treatment reduced hypersensitivity (p < 0.01). VPA was significantly effective only after 1 month (p < 0.01). All the three receptors are involved in BUT + VPA effects (p < 0.001). BUT and BUT + VPA decreased the expression of NFkB and enhanced glutathione reductase (p < 0.01); protein oxidation (carbonylation) was reduced (p < 0.01). No effect was reported with VPA. In conclusion BUT, alone or in coadministration with VPA, is a valuable candidate for managing the epilepsy-related persistent pain

A novel cancer vaccine for melanoma based on an approved vaccine against measles, mumps, and rubella

Common vaccines for infectious diseases have been repurposed as cancer immunotherapies. The intratumoral administration of these repurposed vaccines can induce immune cell infiltra-tion into the treated tumor. Here, we have used an approved trivalent live attenuated measles, mumps, and rubella (MMR) vaccine in our previously developed PeptiENV cancer vaccine platform. The intratumoral administration of this novel MMR-containing PeptiENV cancer vaccine significantly increased both intratumoral as well as systemic tumor-specific T cell responses. In addition, PeptiENV therapy, in combination with immune checkpoint inhibitor therapy, improved tumor growth control and survival as well as increased the number of mice responsive to immune checkpoint inhibitor therapy. Importantly, mice pre-vaccinated with the MMR vaccine responded equally well, if not better, to the PeptiENV therapy, indicating that pre-existing immunity against the MMR vaccine viruses does not compromise the use of this novel cancer vaccine platform.Peer reviewe